Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots against carbon tetrachloride treated hepatic injury in rats

Ginseng (Panax ginseng C. A. Meyer) has a beneficial role in the treatment of various diseases including liver disorders like acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis and hepatocellular carcinoma. Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract w...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2014-12, Vol.158, p.442-446
Main Authors: Niranjana Murthy, Hosakatte, Dandin, Vijayalaxmi S., Yoeup Paek, Kee
Format: Article
Language:English
Subjects:
Animals
Carbon Tetrachloride Poisoning - prevention & control
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - prevention & control
Ginsenosides
Ginsenosides - pharmacology
Glutathione
Hepatoprotective activity
Lipid peroxidation
Male
Mountain ginseng
Panax - chemistry
Plant Roots - chemistry
Rats
Rats, Sprague-Dawley
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Summary:Ginseng (Panax ginseng C. A. Meyer) has a beneficial role in the treatment of various diseases including liver disorders like acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis and hepatocellular carcinoma. Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract with ginsenosides in abundance was used as an experimental material. ‘Sprague–Dawley’ male rats were used as experimental systems and were fed with TCMGARs extracts at doses of 30, 100, 300mg/kg body weight for two weeks to test the effect on carbon tetrachloride (CCl4) induced acute liver damage. Field cultivated Korean ginseng root extract fed rats (100mg/kg) were used as positive control. Plasma enzyme levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were assessed. Glutathione (GSH) and malondialdehyde (MDA) concentrations were also evaluated. TCMGARs extracts remarkably prevented the elevation of ALT, AST, ALP and liver peroxides in CCl4-treated rats. Hepatic glutathione levels were significantly increased by the treatment with the extracts in experimental groups. The TCMGARs rich in varied ginsenosides can afford protection against CCl4-induced hepatocellular injury. [Display omitted]
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2014.10.047