Stromal cells attenuate the cytotoxicity of imatinib on Philadelphia chromosome-positive leukemia cells by up-regulating the VE-cadherin/β-catenin signal

Highlights • Stromal cells can reduce the cytotoxicity of imatinib on Ph+ leukemic cells. • Stromal cells can upregualte VE-cadherin expression in Ph+ leukemia cells. • VE-cadherin can modulate imatinib sensitivity via regulating β-catenin signal in Ph+ leukemia cells.

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Bibliographic Details
Published in:Leukemia research 2014-12, Vol.38 (12), p.1460-1468
Main Authors: Chen, Chong, Zhang, Huan-Xin, Wang, Man, Song, Xu-Guang, Cao, Jiang, Wang, Lin, Qiao, Jian-Lin, Lu, Xiao-Yun, Han, Zheng-Xiang, Zhu, Ping, Pan, Bin, Wu, Qing-Yun, Zhao, Kai, Yan, Zhi-Ling, Li, Zhen-Yu, Zeng, Ling-Yu, Xu, Kai-Lin
Format: Article
Language:English
Subjects:
Antigens, CD - biosynthesis
Antineoplastic Agents - pharmacology
Benzamides - pharmacology
beta Catenin - biosynthesis
Cadherins - biosynthesis
Cell Line, Tumor
Coculture Techniques
Drug Resistance, Neoplasm - drug effects
Gene Expression Regulation, Leukemic - drug effects
Hematology, Oncology and Palliative Medicine
Humans
Imatinib
Imatinib Mesylate
K562 Cells
Leukemia - drug therapy
Leukemia - metabolism
Leukemia - pathology
Neoplasm Proteins - biosynthesis
Ph+ leukemia
Philadelphia Chromosome
Piperazines - pharmacology
Pyrimidines - pharmacology
Signal Transduction - drug effects
Stromal cells
Stromal Cells - metabolism
Stromal Cells - pathology
Up-Regulation - drug effects
VE-cadherin
β-Catenin
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Description
Summary:Highlights • Stromal cells can reduce the cytotoxicity of imatinib on Ph+ leukemic cells. • Stromal cells can upregualte VE-cadherin expression in Ph+ leukemia cells. • VE-cadherin can modulate imatinib sensitivity via regulating β-catenin signal in Ph+ leukemia cells.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2014.09.012