Anti–citrullinated protein antibody positivity correlates with cartilage damage and proteoglycan levels in patients with rheumatoid arthritis in the hand joints

Objective: To investigate the factors associated with cartilage proteoglycan content in patients with rheumatoid arthritis (RA) Methods: 32 RA patients received high-field 3 Tesla Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) for determining cartilage proteoglycan content. Measurements were perform...

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Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2014-12, Vol.66 (12), p.3283-3288
Main Authors: Renner, Nina, Krönke, Gerhard, Rech, Jürgen, Uder, Michael, Janka, Rolf, Lauer, Lars, Paul, Dominik, Herz, Barbara, Schlechtweg, Philipp, Hennig, Friedrich Frank, Schett, Georg, Welsch, Götz
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - immunology
Autoantibodies - analysis
Cartilage - chemistry
Female
Humans
Magnetic Resonance Imaging
Male
Metacarpophalangeal Joint - immunology
Middle Aged
Proteoglycans - analysis
Young Adult
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Summary:Objective: To investigate the factors associated with cartilage proteoglycan content in patients with rheumatoid arthritis (RA) Methods: 32 RA patients received high-field 3 Tesla Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) for determining cartilage proteoglycan content. Measurements were performed in three individual cartilage regions (medial, central, lateral) of the metacarpophalangeal joints 2 and 3. dGEMRIC values were then related to disease duration, disease activity, anti-citrullinated protein antibody (ACPA) status, rheumatoid factor status and C-reactive protein level. Results: dGEMRIC values were not significantly different between the MCP2 and MCP3 joint. Inter-class correlations were high (>0.92) for all three (medial, central and lateral) cartilage compartments. dGEMRIC values were significantly lower in RA patients with longer disease duration (≥3 years) and those with ACPA positivity than those with a short disease duration (
ISSN:2326-5205
DOI:10.1002/art.38862