Communication: nanosecond folding dynamics of an alpha helix: time-dependent 2D-IR cross peaks observed using polarization-sensitive dispersed pump-probe spectroscopy

We present a simple method to measure the dynamics of cross peaks in time-resolved two-dimensional vibrational spectroscopy. By combining suitably weighted dispersed pump-probe spectra, we eliminate the diagonal contribution to the 2D-IR response, so that the dispersed pump-probe signal contains the...

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Bibliographic Details
Published in:The Journal of chemical physics 2015-01, Vol.142 (4), p.041103-041103
Main Authors: Panman, Matthijs R, van Dijk, Chris N, Meuzelaar, Heleen, Woutersen, S
Format: Article
Language:English
Subjects:
Dispersion
Folding
Spectrum analysis
Time dependence
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Summary:We present a simple method to measure the dynamics of cross peaks in time-resolved two-dimensional vibrational spectroscopy. By combining suitably weighted dispersed pump-probe spectra, we eliminate the diagonal contribution to the 2D-IR response, so that the dispersed pump-probe signal contains the projection of only the cross peaks onto one of the axes of the 2D-IR spectrum. We apply the method to investigate the folding dynamics of an alpha-helical peptide in a temperature-jump experiment and find characteristic folding and unfolding time constants of 260 ± 30 and 580 ± 70 ns at 298 K.
ISSN:0021-9606
1089-7690
DOI:10.1063/1.4906456