Meta-analysis of superficial versus deep injection of radioactive tracer and blue dye for lymphatic mapping and detection of sentinel lymph nodes in breast cancer

Background Sentinel lymph node biopsy (SLNB) is the standard of care for axillary staging in early breast cancer. Currently, no consensus exists on the optimal site of injection of the radioactive tracer or blue dye. Methods A systematic review and meta‐analysis of studies comparing superficial and...

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Bibliographic Details
Published in:British journal of surgery 2015-02, Vol.102 (3), p.169-181
Main Authors: Ahmed, M., Purushotham, A. D., Horgan, K., Klaase, J. M., Douek, M.
Format: Article
Language:English
Subjects:
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cohort Studies
Coloring Agents - administration & dosage
Female
Humans
Image-Guided Biopsy - methods
Injections
Intraoperative Care
Lymph Nodes - pathology
Lymphatic Metastasis
Lymphoscintigraphy - methods
Radioactive Tracers
Radioisotopes - administration & dosage
Randomized Controlled Trials as Topic
Sentinel Lymph Node Biopsy - methods
Treatment Outcome
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Summary:Background Sentinel lymph node biopsy (SLNB) is the standard of care for axillary staging in early breast cancer. Currently, no consensus exists on the optimal site of injection of the radioactive tracer or blue dye. Methods A systematic review and meta‐analysis of studies comparing superficial and deep injections of radioactive tracer or blue dye for lymphatic mapping and SLNB was performed. The axillary and extra‐axillary sentinel lymph node (SLN) identification rates obtained by lymphoscintigraphy and intraoperative SLNB were evaluated. Pooled odds ratios (ORs) and 95 per cent c.i. were estimated using fixed‐effect analyses, or random‐effects analyses if there was statistically significant heterogeneity (P 
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.9673