Quantitative Measures of Physical Functioning After Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma: A Feasibility Study

Micro-Abstract Cardiopulmonary exercise testing (CPET) and 6-minute walk testing (6MWT) are important, quantitative measures of physical function, but they have not been tested in patients who have undergone stem cell transplant for multiple myeloma. Twenty-two post-transplant myeloma patients under...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2015-02, Vol.15 (2), p.103-109
Main Authors: Tuchman, Sascha A, Lane, Amy, Hornsby, Whitney E, Bishop, Caroline, Thomas, Samantha, Herndon, James E, Long, Gwynn, Gasparetto, Cristina, Jones, Lee W
Format: Article
Language:English
Subjects:
Aged
Cardiorespiratory fitness
Chemotherapy
Exercise Test
Exercise tolerance
Feasibility Studies
Female
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cell Transplantation - methods
Humans
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - physiopathology
Transplantation
Transplantation Conditioning - methods
Transplantation, Autologous - methods
Treatment Outcome
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Summary:Micro-Abstract Cardiopulmonary exercise testing (CPET) and 6-minute walk testing (6MWT) are important, quantitative measures of physical function, but they have not been tested in patients who have undergone stem cell transplant for multiple myeloma. Twenty-two post-transplant myeloma patients underwent CPET and 6MWT, and assessment of patient-reported outcomes (PROs). Patients had marked reductions in performance on CPET and 6MWT, but no correlation was seen with PROs. Further study is needed to better understand the meaning of this finding of persistently impaired physical function in myeloma patients more than a year post-transplant.
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2014.09.002