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Hepatitis C Virus-Specific Cytolytic T Lymphocyte and T Helper Cell Responses in Seronegative Persons
Hepatitis C virus (HCV) is a common infection worldwide, and in most persons, it leads to persistent viremia and liver damage. Efforts to identify the correlates of protective immunity are hampered by this high rate of persistent infection in both infected humans and the only animal model, the chimp...
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| Published in: | The Journal of infectious diseases 1997-10, Vol.176 (4), p.859-866 |
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| Main Authors: | , , , , |
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| container_end_page | 866 |
| container_issue | 4 |
| container_start_page | 859 |
| container_title | The Journal of infectious diseases |
| container_volume | 176 |
| creator | Koziel, Margaret James Wong, David K. H. Dudley, Darryll Houghton, Michael Walker, Bruce D. |
| description | Hepatitis C virus (HCV) is a common infection worldwide, and in most persons, it leads to persistent viremia and liver damage. Efforts to identify the correlates of protective immunity are hampered by this high rate of persistent infection in both infected humans and the only animal model, the chimpanzee. Peripheral blood mononuclear cells from seronegative persons were stimulated with synthetic peptides that represent epitopes recognized by HCV-specific cytotoxic T lymphocytes (CTL) after natural infection. In addition, CD4+ proliferative responses to recombinant HCV proteins were examined in these same persons. CTL responses directed against a peptide epitope of HCV and proliferative responses in 2 HCV-seronegative persons with possible occupational exposure to HCV were found. These otherwise healthy persons were not viremic, suggesting that they may have recovered from acute HCV infection. Characterization of virus-specific immune responses in exposed but seronegative persons may provide important clues as to the nature of protective immunity in HCV. |
| doi_str_mv | 10.1086/516546 |
| format | article |
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CTL responses directed against a peptide epitope of HCV and proliferative responses in 2 HCV-seronegative persons with possible occupational exposure to HCV were found. These otherwise healthy persons were not viremic, suggesting that they may have recovered from acute HCV infection. 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H.</creatorcontrib><creatorcontrib>Dudley, Darryll</creatorcontrib><creatorcontrib>Houghton, Michael</creatorcontrib><creatorcontrib>Walker, Bruce D.</creatorcontrib><title>Hepatitis C Virus-Specific Cytolytic T Lymphocyte and T Helper Cell Responses in Seronegative Persons</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Hepatitis C virus (HCV) is a common infection worldwide, and in most persons, it leads to persistent viremia and liver damage. Efforts to identify the correlates of protective immunity are hampered by this high rate of persistent infection in both infected humans and the only animal model, the chimpanzee. Peripheral blood mononuclear cells from seronegative persons were stimulated with synthetic peptides that represent epitopes recognized by HCV-specific cytotoxic T lymphocytes (CTL) after natural infection. In addition, CD4+ proliferative responses to recombinant HCV proteins were examined in these same persons. CTL responses directed against a peptide epitope of HCV and proliferative responses in 2 HCV-seronegative persons with possible occupational exposure to HCV were found. These otherwise healthy persons were not viremic, suggesting that they may have recovered from acute HCV infection. Characterization of virus-specific immune responses in exposed but seronegative persons may provide important clues as to the nature of protective immunity in HCV.</description><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Candida - immunology</subject><subject>Cell Division</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Epitopes</subject><subject>Epitopes - immunology</subject><subject>Hepacivirus</subject><subject>Hepatitis C</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C Antigens - immunology</subject><subject>Histocompatibility Testing</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HLA antigens</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Laboratory Infection - immunology</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Medical sciences</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - immunology</subject><subject>Recombinant Proteins - immunology</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Tuberculin</subject><subject>Tumor Cells, Cultured</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - immunology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpdkF2L1DAYhYMo67jqPxCCiHfVfKe5lKJWGFDccRFvQiZ9qxk7bU1Ssf_eyAyz4FVe8jwcDgehp5S8oqRWryVVUqh7aEMl15VSlN9HG0IYq2htzEP0KKUDIURwpa_QleGcU8E2CFqYXQ45JNzg2xCXVN3M4EMfPG7WPA1rLtcOb9fj_GPyawbsxq58tDDMEHEDw4A_Q5qnMUHCYcQ3EKcRvpfQ34A_QUyFPEYPejckeHJ-r9GXd293TVttP77_0LzZVl5InquaCW58x0wHymkmTA-MS8Zq57TrNYVaEe_3UjDQnNXAmTau7kwn951nGvg1ennKneP0a4GU7TEkXyq6EaYl2bIRE0LJIj7_TzxMSxxLN8sYN5Rooe7SfJxSitDbOYaji6ulxP4b3Z5GL-Kzc9qyP0J30c4rF_7izF3ybuijG31IF43VnDBC72IOKU_xgjkpdaQyhVcnHlKGPxfu4k-rNNfStl-_2faWcKl31O74Xw2_n68</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Koziel, Margaret James</creator><creator>Wong, David K. 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| ispartof | The Journal of infectious diseases, 1997-10, Vol.176 (4), p.859-866 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list) |
| subjects | Antigens Biological and medical sciences Candida - immunology Cell Division Cytotoxicity Tests, Immunologic Epitopes Epitopes - immunology Hepacivirus Hepatitis C Hepatitis C - immunology Hepatitis C Antigens - immunology Histocompatibility Testing HIV HIV 1 HLA antigens Human viral diseases Humans Infections Infectious diseases Laboratory Infection - immunology Leukocytes, Mononuclear - immunology Medical sciences Peptides - chemical synthesis Peptides - immunology Recombinant Proteins - immunology T lymphocytes T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology Tuberculin Tumor Cells, Cultured Viral diseases Viral hepatitis Viral Proteins - genetics Viral Proteins - immunology Viruses |
| title | Hepatitis C Virus-Specific Cytolytic T Lymphocyte and T Helper Cell Responses in Seronegative Persons |
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