New Observations Regarding Post-Ischemia/Reperfusion Myocardial Swelling

When reperfusion occurs, these cells are exposed to a sudden influx of fluids and electrolytes. Because these cells have sarcolemmal membrane defects resulting in impaired volume control, fluids, sodium, and calcium overwhelm them, leading to "explosive cell swelling" (6) within seconds to...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-02, Vol.65 (4), p.324-326
Main Author: Kloner, Robert A., MD, PhD
Format: Article
Language:English
Subjects:
Animals
Cardiology
Cardiovascular
cellular edema
Edema - etiology
Fluids
Heart attacks
imaging
Internal Medicine
Ischemia
Laboratories
magnetic resonance
Male
Mitochondria
myocardial infarction
myocardial ischemia
Myocardial Reperfusion Injury - complications
NMR
Nuclear magnetic resonance
reperfusion
Rodents
Studies
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Summary:When reperfusion occurs, these cells are exposed to a sudden influx of fluids and electrolytes. Because these cells have sarcolemmal membrane defects resulting in impaired volume control, fluids, sodium, and calcium overwhelm them, leading to "explosive cell swelling" (6) within seconds to minutes of reperfusion. [...]myocardial edema followed a bimodal pattern.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.11.006