All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause

•Menopause-arrest of estrogen and progesterone secretion by the ovaries.•After menopause, all sex steroids are made intracellularly from DHEA.•After menopause, it is estimated that 80% and 20% of DHEA are from adrenal and ovarian origins, respectively.•After menopause, serum estradiol is maintained...

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2015-01, Vol.145, p.133-138
Main Author: Labrie, Fernand
Format: Article
Language:English
Subjects:
Androgens
Aromatase Inhibitors - pharmacology
Breast cancer
Breast Neoplasms - metabolism
Dehydroepiandrosterone
Dehydroepiandrosterone - metabolism
Estrogen Receptor Modulators - pharmacology
Estrogens
Estrogens - biosynthesis
Estrogens - secretion
Female
Humans
Hydrocortisone - metabolism
Intracrinology
Menopause
Ovary - metabolism
Progesterone - biosynthesis
Progesterone - secretion
Steroids - biosynthesis
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Summary:•Menopause-arrest of estrogen and progesterone secretion by the ovaries.•After menopause, all sex steroids are made intracellularly from DHEA.•After menopause, it is estimated that 80% and 20% of DHEA are from adrenal and ovarian origins, respectively.•After menopause, serum estradiol is maintained at non biological significant levels (
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2014.06.001