Cardiovascular Complications in Diabetic Patients Undergoing Regular Hemodialysis: A 5-Year Observational Study

We aimed to study the vascular outcomes in hemodialysis (HD) patients based on their diabetic status. A cohort observational study was conducted among patients undergoing regular HD with a 5-year follow-up. Of the 252 consecutive HD patients, 60% were diabetic. Compared with nondiabetics, diabetics...

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Bibliographic Details
Published in:Angiology 2015-03, Vol.66 (3), p.225-230
Main Authors: Al-Thani, Hassan, Shabana, Adel, Hussein, Ahmed, Sadek, Ahmed, Sharaf, Ahmed, Koshy, Valsa, El-Menyar, Ayman
Format: Article
Language:English
Subjects:
Adult
Aged
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Cardiovascular Diseases - therapy
Case-Control Studies
Chi-Square Distribution
Diabetic Nephropathies - diagnosis
Diabetic Nephropathies - etiology
Diabetic Nephropathies - mortality
Diabetic Nephropathies - therapy
Female
Humans
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - therapy
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Qatar
Renal Dialysis - adverse effects
Risk Factors
Time Factors
Treatment Outcome
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Summary:We aimed to study the vascular outcomes in hemodialysis (HD) patients based on their diabetic status. A cohort observational study was conducted among patients undergoing regular HD with a 5-year follow-up. Of the 252 consecutive HD patients, 60% were diabetic. Compared with nondiabetics, diabetics were 11 years older, 4 years lesser on HD, and more likely to have prior cerebrovascular and coronary artery disease (CAD). Overall 5-year follow-up showed that diabetic patients had higher rates of HD vascular accesses (57% vs 41%, P = .01), CAD (64% vs 33%, P = .001), major amputations (8.6% vs 0%, P = .003), and mortality (66% vs 23%, P = .001). On multivariate analysis, independent predictors of mortality included number of vascular accesses in nondiabetics and HD duration, CAD, and peripheral artery disease in diabetic patients. Diabetes mellitus is associated with a significant vascular burden and mortality among HD patients. Moreover, our finding highlights the vascular impact of renal failure and HD.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319714523672