Association of Plasma Brain Natriuretic Peptide Levels in Acute Ischemic Stroke Subtypes and Outcome

Background Brain natriuretic peptide (BNP) is believed to be a diagnostic marker for cardiovascular diseases, including atrial fibrillation (AF). Recent studies have incriminated BNP as a marker of cardioembolic stroke. We aimed at investigating association of plasma BNP levels in acute ischemic str...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2015-02, Vol.24 (2), p.485-491
Main Authors: Chaudhuri, Jaydip Ray, MD, DM, Sharma, Vijay Kumar, MD, Mridula, Kandadai Rukmini, DNB, DM, Balaraju, Banda, MD, Bandaru, Venkata Chandra Sekher Srinivasarao, PhD
Format: Article
Language:English
Subjects:
Acute ischemic stroke
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Blood Pressure
BNP
Brain Ischemia - blood
Brain Ischemia - classification
Brain Ischemia - mortality
cardioembolic stroke
Cardiovascular
Female
Follow-Up Studies
Humans
India
Indian patients
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Neurology
Prognosis
Risk Factors
Stroke - blood
Stroke - classification
Stroke - mortality
Young Adult
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Summary:Background Brain natriuretic peptide (BNP) is believed to be a diagnostic marker for cardiovascular diseases, including atrial fibrillation (AF). Recent studies have incriminated BNP as a marker of cardioembolic stroke. We aimed at investigating association of plasma BNP levels in acute ischemic stroke subtypes and their outcome in Indian patients. Methods We recruited 270 acute ischemic stroke patients within 48 hours of symptom onset and compared with 110 age- and sex-matched control subjects. This study was carried out at Yashoda Hospital, Hyderabad, India between April 2011 and March 2013. Serum BNP levels were estimated in stroke patients and control subjects. Good functional outcome at 3 months was defined as modified Rankin score (mRS) 2 or less. Results Elevated BNP levels was significantly more in patients with acute ischemic stroke patients 119 (44%) compared with controls 4 (3.6%; P  
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2014.09.025