Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric Peptides Inhibiting Candida albicans Isocitrate Lyase

Mohangamides A and B (1–2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectros...

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Bibliographic Details
Published in:Organic letters 2015-02, Vol.17 (3), p.712-715
Main Authors: Bae, Munhyung, Kim, Heegyu, Moon, Kyuho, Nam, Sang-Jip, Shin, Jongheon, Oh, Ki-Bong, Oh, Dong-Chan
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Aspergillus fumigatus - drug effects
Candida albicans - drug effects
Candida albicans - enzymology
Isocitrate Lyase - drug effects
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Trichophyton - drug effects
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Summary:Mohangamides A and B (1–2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectroscopic analysis. The absolute configurations of the mohangamides were determined by chemical derivatizations, followed by chromatographic and spectroscopic analyses. Mohangamide A displayed strong inhibitory activity against Candida albicans isocitrate lyase.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol5037248