Gender-specific relationships between plasma oxidized low-density lipoprotein cholesterol, total antioxidant capacity, and central adiposity indicators

Background: Oxidative stress has a pivotal role in the onset of obesity-related chronic diseases. This study assessed potential gender differences in the associations of adiposity (total vs. central) with oxidative stress markers in healthy young adults. Methods: This cross-sectional study enrolled...

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Published in:European journal of preventive cardiology 2014-07, Vol.21 (7), p.884-891
Main Authors: Hermsdorff, Helen Hermana M, Barbosa, Kiriaque BF, Volp, Ana Carolina P, Puchau, Blanca, Bressan, Josefina, Zulet, M Ángeles, Martínez, J Alfredo
Format: Article
Language:English
Subjects:
Adiposity - physiology
Adult
Antioxidants - metabolism
Biological and medical sciences
Biomarkers - blood
Body Composition
Cardiology. Vascular system
Cross-Sectional Studies
Female
Glutathione Peroxidase - blood
Heart
Humans
Lipoproteins, LDL - blood
Male
Medical sciences
Obesity - metabolism
Oxidative Stress - physiology
Sex Factors
Young Adult
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Summary:Background: Oxidative stress has a pivotal role in the onset of obesity-related chronic diseases. This study assessed potential gender differences in the associations of adiposity (total vs. central) with oxidative stress markers in healthy young adults. Methods: This cross-sectional study enrolled 272 subjects (97 males, 175 females; 22 ± 3 years, body mass index 22.0 ± 2.8 kg/m2). Body composition, cardiometabolic and lifestyle features, oxidized low-density lipoprotein cholesterol (ox-LDL) concentrations, plasma total antioxidant capacity (TAC), and glutathione peroxidase (GPx) activity in erythrocytes were determined by validated procedures. Results: Compared to women, men had statistically higher concentrations of ox-LDL (61.7 vs. 53.5 U/l, p = 0.022). In analyses with the whole sample, those individuals included in the highest tertile of central adiposity indicators (waist circumference, WC, or waist-to-hip ratio, WHR) presented higher ox-LDL and lower TAC values (p  0.05) after individual pairing of men and women for WC (53.8 vs. 61.6 U/l, p = 0.225) or WHR (56.1 vs. 56.3 U/l, p = 0.471). No differences were found in GPx values concerning gender or adiposity indicators. Conclusions: Plasma ox-LDL and TAC values were more strongly influenced by central adiposity indicators (WHR and WC) in women than in men, suggesting that the change of the gynoid to android pattern phenotype among young women could lead to a steeper unfavourable redox status compared to men.
ISSN:2047-4873
2047-4881
DOI:10.1177/2047487312472420