Impact of ertapenem on antimicrobial resistance in a sentinel group of Gram-negative bacilli: a 6 year antimicrobial resistance surveillance study

• Published in: Journal of antimicrobial chemotherapy 2015-03, Vol.70 (3), p.914-921
• Main Authors: Rodriguez-Osorio, Carlos A, Sanchez-Martinez, Cesar O, Araujo-Melendez, Javier, Criollo, Elia, Macias-Hernandez, Alejandro E, Ponce-de-Leon, Alfredo, Ponce-de-Leon, Sergio, Sifuentes-Osornio, Jose
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - therapeutic use; beta-Lactams - therapeutic use; Drug resistance; Drug Resistance, Bacterial; E coli; Gram-negative bacteria; Gram-Negative Bacteria - drug effects; Gram-Negative Bacterial Infections - drug therapy; Gram-Negative Bacterial Infections - microbiology; Humans; Microbial Sensitivity Tests; Regression analysis; Retrospective Studies; Sentinel Surveillance; Surveillance; Tertiary Care Centers
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dku471

To determine the association between ertapenem and resistance of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii-calcoaceticus complex to different antimicrobials while adjusting for relevant hospital factors. This was a retrospective time-series study conducted at a tertiary care centre from September 2002 to August 2008. The specific impact of ertapenem on the resistance of these Gram-negative bacilli (GNB) was assessed by multiple linear regression analysis, adjusting for the average length of stay, rate of hospital-acquired infections and use of 10 other antimicrobials, including type 2 carbapenems. Unadjusted analyses revealed significant increases over the duration of the study in the number of GNB resistant to meropenem/imipenem among 1000 isolates each of E. coli (0.46 ± 0.22, P