6-OH-BDE-47 promotes human lung cancer cells epithelial mesenchymal transition via the AKT/Snail signal pathway

Highlights • 6-OH-BDE-47 induced the EMT of lung cancer cells. • Snail was essential for 6-OH-BDE-47 induced the EMT. • 6-OH-BDE-47 up regulated the stabilization of Snail. • 6-OH-BDE-47 up regulated Snail via PI3K/AKT.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-01, Vol.39 (1), p.271-279
Main Authors: Qu, Bao-Lin, Yu, Wei, Huang, Yu-Rong, Cai, Bo-Ning, Du, Le-Hui, Liu, Fang
Format: Article
Language:English
Subjects:
6-OH-BDE-47
Cell Line, Tumor
Cell Movement - drug effects
Emergency
Epithelial to mesenchymal transition
Epithelial-Mesenchymal Transition - drug effects
Humans
Lung cancer
Lung Neoplasms - metabolism
Polybrominated Biphenyls - toxicity
Proto-Oncogene Proteins c-akt - metabolism
RNA, Messenger - metabolism
RNA, Small Interfering - genetics
Signal Transduction - drug effects
Snail
Snail Family Transcription Factors
Transcription Factors - genetics
Transcription Factors - metabolism
Wound Healing - drug effects
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Description
Summary:Highlights • 6-OH-BDE-47 induced the EMT of lung cancer cells. • Snail was essential for 6-OH-BDE-47 induced the EMT. • 6-OH-BDE-47 up regulated the stabilization of Snail. • 6-OH-BDE-47 up regulated Snail via PI3K/AKT.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2014.11.022