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6-OH-BDE-47 promotes human lung cancer cells epithelial mesenchymal transition via the AKT/Snail signal pathway

Highlights • 6-OH-BDE-47 induced the EMT of lung cancer cells. • Snail was essential for 6-OH-BDE-47 induced the EMT. • 6-OH-BDE-47 up regulated the stabilization of Snail. • 6-OH-BDE-47 up regulated Snail via PI3K/AKT.

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Published in:	Environmental toxicology and pharmacology 2015-01, Vol.39 (1), p.271-279
Main Authors:	Qu, Bao-Lin, Yu, Wei, Huang, Yu-Rong, Cai, Bo-Ning, Du, Le-Hui, Liu, Fang
Format:	Article
Language:	English
Subjects:	6-OH-BDE-47 Cell Line, Tumor Cell Movement - drug effects Emergency Epithelial to mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Humans Lung cancer Lung Neoplasms - metabolism Polybrominated Biphenyls - toxicity Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism RNA, Small Interfering - genetics Signal Transduction - drug effects Snail Snail Family Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Wound Healing - drug effects
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cited_by	cdi_FETCH-LOGICAL-c411t-f7ffd954c489918ac589e36cf1900d618f47428fae6816099f8798855025aa173
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container_end_page	279
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container_title	Environmental toxicology and pharmacology
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creator	Qu, Bao-Lin Yu, Wei Huang, Yu-Rong Cai, Bo-Ning Du, Le-Hui Liu, Fang
description	Highlights • 6-OH-BDE-47 induced the EMT of lung cancer cells. • Snail was essential for 6-OH-BDE-47 induced the EMT. • 6-OH-BDE-47 up regulated the stabilization of Snail. • 6-OH-BDE-47 up regulated Snail via PI3K/AKT.
doi_str_mv	10.1016/j.etap.2014.11.022
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subjects	6-OH-BDE-47 Cell Line, Tumor Cell Movement - drug effects Emergency Epithelial to mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Humans Lung cancer Lung Neoplasms - metabolism Polybrominated Biphenyls - toxicity Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism RNA, Small Interfering - genetics Signal Transduction - drug effects Snail Snail Family Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Wound Healing - drug effects
title	6-OH-BDE-47 promotes human lung cancer cells epithelial mesenchymal transition via the AKT/Snail signal pathway
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