Advances in targeted therapy for unresectable melanoma: New drugs and combinations

Highlights • This article is to overview the recent progress of targeted therapies for unresectable melanoma. • Targeted therapy has emerged and achieved great progress in decades. • Currently, the targeted therapy is a hot spot for clinical studies. • Combined with the latest clinical results from...

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Bibliographic Details
Published in:Cancer letters 2015-04, Vol.359 (1), p.1-8
Main Authors: Hao, Mengze, Song, Fengju, Du, Xiaoling, Wang, Guowen, Yang, Yun, Chen, Kexin, Yang, Jilong
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - therapeutic use
Animals
Anorexia
Antibodies - therapeutic use
Antineoplastic Agents - therapeutic use
Apoptosis
BRAF
c-KIT
Cell growth
Clinical trials
CTLA-4
Diarrhea
Drug Design
Drug resistance
Drug therapy
FDA approval
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Medical prognosis
MEK
Melanoma
Melanoma - drug therapy
Melanoma - enzymology
Melanoma - genetics
Melanoma - pathology
Metastasis
Molecular Targeted Therapy - trends
Mutation
Nausea
PD-1/L1
PI3K/Akt/mTOR
Protein Kinase Inhibitors - therapeutic use
Signal Transduction - drug effects
Skin cancer
Skin Neoplasms - drug therapy
Skin Neoplasms - enzymology
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Treatment Outcome
Tumors
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Summary:Highlights • This article is to overview the recent progress of targeted therapies for unresectable melanoma. • Targeted therapy has emerged and achieved great progress in decades. • Currently, the targeted therapy is a hot spot for clinical studies. • Combined with the latest clinical results from 2014 ASCO meeting, this essay would focus on potential targeted drugs and combinations for advanced melanoma.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.12.050