An isobolographic analysis of drug interaction between intrathecal clonidine and baclofen in the formalin test in rats

The inhibition of both phases of the formalin response by intrathecal (IT) clonidine and baclofen, given alone or in combination at a fixed dose ratio, was studied. Both drugs, at doses not affecting motor performance, produced a dose-dependent inhibition of phase 2 of the formalin test. The potency...

Full description

Saved in:
Bibliographic Details
Published in:Neuropharmacology 1998-01, Vol.37 (2), p.207-214
Main Authors: Przesmycki, Krzysztof, Dzieciuch, Jacek A, Czuczwar, Stanisław J, Kleinrok, Zdzisław
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - pharmacology
Adrenergic alpha-Antagonists - pharmacology
Analgesics
Animals
Baclofen
Baclofen - pharmacology
Biological and medical sciences
Clonidine
Clonidine - pharmacology
Drug Interactions
Formaldehyde
Formalin test
GABA Agonists - pharmacology
Imidazoles - pharmacology
Injections, Spinal
Male
Medical sciences
Motor Activity - drug effects
Neuropharmacology
Nociception
Pain Threshold - drug effects
Pharmacology. Drug treatments
Rats
Rats, Wistar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The inhibition of both phases of the formalin response by intrathecal (IT) clonidine and baclofen, given alone or in combination at a fixed dose ratio, was studied. Both drugs, at doses not affecting motor performance, produced a dose-dependent inhibition of phase 2 of the formalin test. The potency of baclofen and clonidine, defined by their ID 50's for phase 2 of the formalin test, was 0.56 and 3.4 nmol, respectively. The combination ID 50 of baclofen and clonidine, with the equieffective dose ratio of 1:6, was found to be statistically lower than the theoretical additive ID 50. These data suggest that co-administration of α 2-adrenoceptor or GABA B receptor agonists may prove therapeutically useful in treating chronic pain.
ISSN:0028-3908
1873-7064
DOI:10.1016/S0028-3908(98)00004-5