Rapid loss of CD4 super(+) T cells in human-PBL-SCID mice by noncytopathic HIV isolates

Human immunodeficiency virus (HIV) isolates differ in cell tropism, replication, pathogenicity, and syncytial induction in vitro. CD4 super(+) T cells were enumerated in severe combined immunodeficient mice transplanted with human peripheral blood leukocytes (hu-PBL-SCID mice) and infected with HIV...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-01, Vol.260 (5108), p.689-692
Main Authors: Mosier, DE, Gulizia, R J, Maclsaac, P D, Torbett, B E, Levy, JA
Format: Article
Language:English
Subjects:
human immunodeficiency virus
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Summary:Human immunodeficiency virus (HIV) isolates differ in cell tropism, replication, pathogenicity, and syncytial induction in vitro. CD4 super(+) T cells were enumerated in severe combined immunodeficient mice transplanted with human peripheral blood leukocytes (hu-PBL-SCID mice) and infected with HIV isolates with different in vitro cytopathicity. Two noncytopathic, macrophage-tropic strains, HIV-1 sub(SF162) and HIV-2 sub(UC1), induced extensive CD4 super(+) T cell depletion, whereas HIV-1 sub(SF33), which is highly cytopathic for T cells in vitro, caused little CD4 super(+) T cell depletion at equivalent virus burden. In vitro cytopathicity assays therefore do not predict CD4 depletion in the hu-PBL-SCID model.
ISSN:0036-8075