Balkan endemic nephropathy, the haematopoietic system and the environmental connection

We previously reported the detection of an increased subpopulation of cytotoxic T lymphocytes in patients with Balkan (endemic) nephropathy (BEN) and in area controls (individuals free of clinical syndrome but born in a BEN endemic area and having a family history of BEN). Extending the flow-cytomet...

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Bibliographic Details
Published in:Food and chemical toxicology 1998-03, Vol.36 (3), p.245-247
Main Authors: Tatu, C.A., Drugarin, D., Paunescu, V., Stanescu, D.I., Schneider, F.
Format: Article
Language:English
Subjects:
Anemia - etiology
B-Lymphocytes - physiology
Balkan Nephropathy - epidemiology
Balkan Nephropathy - etiology
Balkan Nephropathy - physiopathology
Biological and medical sciences
Environmental Exposure
Eosinophils - physiology
Hematopoietic System - physiopathology
Humans
Interstitial nephritis
Leukocyte Count
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Romania - epidemiology
T-Lymphocytes, Cytotoxic - physiology
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Summary:We previously reported the detection of an increased subpopulation of cytotoxic T lymphocytes in patients with Balkan (endemic) nephropathy (BEN) and in area controls (individuals free of clinical syndrome but born in a BEN endemic area and having a family history of BEN). Extending the flow-cytometric analyses to other populations of peripheral blood leucocytes, we found a decrease in the proportion of B lymphocyte subset and an increased proportion of eosinophils in BEN patients and in area controls. Although these numerical alterations cannot be categorically linked to the aetiopathogeny of the disease, it is presumed that they can be induced by the same factor(s) causing the kidney damage, through a direct haemato- and lymphotoxic effect.
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(97)00137-3