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Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome

Highlights • Alzheimer's disease (AD) and Down syndrome (DS) share degeneration of nerve growth factor (NGF)-dependent basal forebrain cholinergic neurons. • In AD and DS, NGF synthesis is normal but proNGF is increased. • In both conditions, proNGF maturation is impaired and matrix metalloprot...

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Published in:Trends in pharmacological sciences (Regular ed.) 2014-07, Vol.35 (7), p.338-348
Main Authors: Iulita, M. Florencia, Cuello, A. Claudio
Format: Article
Language:English
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Summary:Highlights • Alzheimer's disease (AD) and Down syndrome (DS) share degeneration of nerve growth factor (NGF)-dependent basal forebrain cholinergic neurons. • In AD and DS, NGF synthesis is normal but proNGF is increased. • In both conditions, proNGF maturation is impaired and matrix metalloprotease 9 activity is increased. • These alterations compromise the availability of NGF to basal forebrain cholinergic neurons. • Biomarkers of NGF metabolic deregulation could signal a central nervous system trophic disconnection.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2014.04.010