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Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome
Highlights • Alzheimer's disease (AD) and Down syndrome (DS) share degeneration of nerve growth factor (NGF)-dependent basal forebrain cholinergic neurons. • In AD and DS, NGF synthesis is normal but proNGF is increased. • In both conditions, proNGF maturation is impaired and matrix metalloprot...
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Published in: | Trends in pharmacological sciences (Regular ed.) 2014-07, Vol.35 (7), p.338-348 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • Alzheimer's disease (AD) and Down syndrome (DS) share degeneration of nerve growth factor (NGF)-dependent basal forebrain cholinergic neurons. • In AD and DS, NGF synthesis is normal but proNGF is increased. • In both conditions, proNGF maturation is impaired and matrix metalloprotease 9 activity is increased. • These alterations compromise the availability of NGF to basal forebrain cholinergic neurons. • Biomarkers of NGF metabolic deregulation could signal a central nervous system trophic disconnection. |
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ISSN: | 0165-6147 1873-3735 |
DOI: | 10.1016/j.tips.2014.04.010 |