Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

Background Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), a marker of oxidative DNA damage, are elevated in alcohol‐dependent patients without delirium tremens (DTs). The aim of this study was to compare...

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Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2014-10, Vol.38 (10), p.2523-2528
Main Authors: Huang, Ming-Chyi, Chen, Chiao-Chicy, Pan, Chun-Hung, Chen, Chun-Hsin
Format: Article
Language:English
Subjects:
8-Hydroxy-2′-Deoxyguanosine
Adult
Alcohol Dependence
Alcohol Withdrawal
Alcohol Withdrawal Delirium - blood
Alcohol Withdrawal Delirium - epidemiology
Alcohol Withdrawal Delirium - physiopathology
Alcoholics
Alcoholism - blood
Alcoholism - epidemiology
Alcoholism - physiopathology
Biomarkers - blood
Comorbidity
Delirium Tremens
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - blood
DNA Damage - physiology
Female
Humans
Male
Middle Aged
Oxidative Stress
Oxidative Stress - physiology
Risk Factors
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Summary:Background Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), a marker of oxidative DNA damage, are elevated in alcohol‐dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8‐OHdG levels between alcohol‐dependent patients with and without DTs. Methods We recruited 16 alcohol‐dependent patients with DTs (DTs group) and 58 patients without DTs (non‐DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA‐Ar‐C) every 8 hours. Serum levels of 8‐OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results The mean 8‐OHdG level in the DTs group was significantly higher than that in the non‐DTs group (0.50 vs. 0.34 ng/ml, p 
ISSN:0145-6008
1530-0277
DOI:10.1111/acer.12539