Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility

The objective of this study was to explore the relationship between single-nucleotide polymorphisms (SNPs) of the protein kinase C gamma (PRKCG) gene and osteosarcoma susceptibility in Chinese Han population. A total of 610 cases of osteosarcoma patients and 610 healthy individuals were enrolled in...

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Bibliographic Details
Published in:Tumor biology 2014-12, Vol.35 (12), p.12671-12677
Main Authors: Zhang, Ying, Hu, Xu, Wang, Hong-Kai, Shen, Wei-Wei, Liao, Tong-Quan, Chen, Pei, Chu, Tong-Wei
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Asian people
Biomedicine
Bone cancer
Cancer Research
Case-Control Studies
Child
Female
Gene Frequency
Genes
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Middle Aged
Odds Ratio
Osteosarcoma - diagnosis
Osteosarcoma - genetics
Polymorphism
Polymorphism, Single Nucleotide
Protein Kinase C - genetics
Research Article
Risk factors
Young Adult
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Summary:The objective of this study was to explore the relationship between single-nucleotide polymorphisms (SNPs) of the protein kinase C gamma (PRKCG) gene and osteosarcoma susceptibility in Chinese Han population. A total of 610 cases of osteosarcoma patients and 610 healthy individuals were enrolled in this study. TaqMan method was used to compare genotypes and the allelic distribution frequency of three SNPs (rs454006, rs2242245, and rs8103851) in the PRKGG gene between osteosarcoma patients and healthy individuals. Osteosarcoma patients were grouped according to different clinical parameters (age, gender, pathological types, tumor location, Enneking staging, tumor metastasis and treatment) to compare genotype and allele frequency among different groups as well as to explore the relationship between gene polymorphisms and different clinical parameters. The rs454006 polymorphisms of the PRKCG gene include the CC, CT, and TT genotypes. The differences in genotype frequency and allele frequency between osteosarcoma patients and healthy individuals were significant (both P   0.05). The differences of the rs8103851 genotype frequency and allele frequency in patients with metastatic osteosarcoma and patients without metastasis were significant (both P  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-2591-8