The Evidence for the Contribution of the Autism Susceptibility Candidate 2 (AUTS2) Gene in Heroin Dependence Susceptibility

The single-nucleotide polymorphisms (SNP) rs6943555 in autism susceptibility candidate 2 (AUTS2) has been reported to be significantly associated with alcohol consumption in Europeans. In this study, we identified the SNP in AUTS2 contributing to the genetic susceptibility to heroin dependence. The...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2014-12, Vol.54 (4), p.811-819
Main Authors: Dang, Wei, Zhang, Qian, Zhu, Yong-Sheng, Lu, Xiao-Yun
Format: Article
Language:English
Subjects:
Adult
Autism
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cell Biology
Female
Heroin Dependence - genetics
Humans
Male
Neurochemistry
Neurology
Neurosciences
Polymorphism, Single Nucleotide
Proteins - genetics
Proteomics
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Summary:The single-nucleotide polymorphisms (SNP) rs6943555 in autism susceptibility candidate 2 (AUTS2) has been reported to be significantly associated with alcohol consumption in Europeans. In this study, we identified the SNP in AUTS2 contributing to the genetic susceptibility to heroin dependence. The potential association between heroin dependence and 21 SNPs (rs2270162, rs2851510, rs513150, rs595681, rs210606, rs10237984, rs13228123, rs10235781, rs6969375, rs6943555, rs10251416, rs17141963, rs12669427, rs723340, rs2293507, rs2293508, rs6960426, rs9886351, rs2293501, rs10277450, rs1918425) of AUTS2 was examined in a Chinese Han population using the MassARRAY system. The participants included 426 patients with heroin dependence and 416 healthy controls. Single SNP association, haplotype association, and clinical phenotype association were analyzed. Single SNP association revealed that AA homozygotes of rs6943555 were significantly over-represented in the patients with heroin dependence compared with the control subjects ( P  = 0.0019). The patients with heroin dependence had a significantly higher frequency of the A allele ( P  = 0.0003, odd ratio (OR) = 1.429, 95 % confidence interval (CI) = 1.175–1.738). Strong linkage disequilibrium (LD) was observed in five blocks (D’ > 0.9). In block 2, significantly more A-A haplotypes ( P  = 0.006 after Bonferroni corrections) and significantly fewer T-A haplotypes ( P  = 0.040) were found in the patients with heroin dependence. The genotype and clinical phenotype correlation study of the rs6943555 carriers showed that the amount of heroin self-injection was lower in the patients with the AA genotype relative to AT + TT genotypes ( P  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-014-0421-5