Fetal death and preterm birth associated with maternal influenza vaccination: systematic review

Background Before 2012, few studies had addressed pregnancy outcomes following maternal influenza vaccination; however, the number of publications on this topic has increased recently. Objectives To review comparative studies evaluating fetal death or preterm birth associated with influenza vaccinat...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2015-01, Vol.122 (1), p.17-26
Main Authors: Fell, DB, Platt, RW, Lanes, A, Wilson, K, Kaufman, JS, Basso, O, Buckeridge, D
Format: Article
Language:English
Subjects:
Female
Fetal Death
Fetal Mortality
Fetuses
Gestational Age
Humans
Immunization
Influenza
influenza vaccination
Influenza Vaccines - therapeutic use
Influenza, Human - prevention & control
monovalent pandemic H1N1 vaccine
Mortality
Perinatal Mortality
Pregnancy
Pregnancy Complications, Infectious - prevention & control
Pregnancy Outcome
Premature birth
Premature Birth - epidemiology
preterm birth
Risk Factors
Systematic review
trivalent inactivated influenza vaccine
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Summary:Background Before 2012, few studies had addressed pregnancy outcomes following maternal influenza vaccination; however, the number of publications on this topic has increased recently. Objectives To review comparative studies evaluating fetal death or preterm birth associated with influenza vaccination during pregnancy. Search strategy We searched bibliographic databases from inception to April 2014. Selection criteria Experimental or observational studies assessing the relationship between influenza vaccination during pregnancy and fetal death or preterm birth. Data collection and analysis Two reviewers independently ed data from studies meeting the inclusion criteria. Main results We included one randomised clinical trial and 26 observational studies. Meta‐analyses were not considered appropriate because of high clinical and statistical heterogeneity. Three studies of fetal death at any gestational age reported adjusted effect estimates in the range 0.56–0.79, and four of five studies of fetal death at
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.12977