Consensus Summary of Aerosolized Antimicrobial Agents: Application of Guideline Criteria

Aerosolized delivery of antimicrobial agents is an attractive option for management of pulmonary infections, as this is an ideal method of providing high local drug concentrations while minimizing systemic exposure. With the paucity of consensus regarding the safety, efficacy, and means with which t...

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Bibliographic Details
Published in:Pharmacotherapy 2010-06, Vol.30 (6), p.562-584
Main Authors: Le Le, Jennifer, Ashley, Elizabeth Dodds, Neuhauser, Melinda M., Brown, Jack, Gentry, Chris, Klepser, Michael E., Marr, Ann Marie, Schiller, Daryl, Schwiesow, Joshua N., Tice, Sally, VandenBussche, Heather L., Wood, G. Christopher
Format: Article
Language:English
Subjects:
aerosolized antibiotic
aerosolized tobramycin
aminoglycosides
antifungal
drug safety
evidence based medicine
infectious diseases
Mycobacterium
nebulized antibiotics
Pneumocystis
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Summary:Aerosolized delivery of antimicrobial agents is an attractive option for management of pulmonary infections, as this is an ideal method of providing high local drug concentrations while minimizing systemic exposure. With the paucity of consensus regarding the safety, efficacy, and means with which to use aerosolized antimicrobials, a task force was created by the Society of Infectious Diseases Pharmacists to critically review and evaluate the literature on the use of aerosolized antiinfective agents. This article summarizes key findings and statements for preventing or treating a variety of infectious diseases, including cystic fibrosis, bronchiecstasis, hospital acquired pneumonia, fungal infections, nontuberculosis mycobacterial infection, and Pneumocystis jiroveci pneumonia. Our intention was to provide guidance for clinicians on the use of aerosolized antibiotics through evidence based pharmacotherapy. Further research with well designed clinical trials is necessary to elucidate the optimal dosage and duration of therapy and, of equal importance, to appreciate the true risks associated with the use of aerosolized delivery systems.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.30.6.562