Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals

Highlights • Pathogen-associated and cell death-associated patterns directly activate dendritic cells (DC). • Directly activated DC cannot present subsequently encountered antigens. • Systemic direct activation of DC causes immunosuppression. • DC can also be activated indirectly by secondary inflam...

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Bibliographic Details
Published in:Current opinion in pharmacology 2014-08, Vol.17, p.64-70
Main Authors: Vega-Ramos, Javier, Roquilly, Antoine, Asehnoune, Karim, Villadangos, Jose A
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Antigen Presentation - drug effects
Communicable Diseases - drug therapy
Communicable Diseases - immunology
Communicable Diseases - metabolism
Dendritic Cells - drug effects
Dendritic Cells - immunology
Drug Design
Host-Pathogen Interactions - drug effects
Humans
Immunologic Factors - therapeutic use
Inflammation - drug therapy
Inflammation - immunology
Inflammation - metabolism
Inflammation Mediators - metabolism
Internal Medicine
Medical Education
Receptors, Immunologic - drug effects
Receptors, Immunologic - metabolism
Signal Transduction - drug effects
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Summary:Highlights • Pathogen-associated and cell death-associated patterns directly activate dendritic cells (DC). • Directly activated DC cannot present subsequently encountered antigens. • Systemic direct activation of DC causes immunosuppression. • DC can also be activated indirectly by secondary inflammatory stimuli. • Direct and indirect modulators of DC interact in poorly understood fashion.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2014.07.013