High seroprevalence of human herpesvirus type 8 in patients with hepatocellular carcinoma

Cirrhosis patients have immunologic insufficiency and a high seroprevalence of human herpesvirus type 8 (HHV-8). Nearly all hepatocellular carcinoma (HCC) patients are cirrhotic and have immunoabnormalities. This study aimed to assess the HHV-8 seroprevalence and hemograms in HCC patients. Blood sam...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2015-01, Vol.34 (1), p.55-62
Main Authors: Su, C.-C., Tseng, K.-C., Lin, M.-N., Hsieh, T.-C., Chu, T.-Y.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Alcohol
Antibodies
Biomedical and Life Sciences
Biomedicine
Buddhism
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - pathology
Deoxyribonucleic acid
DNA
Female
Hepatitis B
Hepatitis C
Herpes viruses
Herpesviridae Infections - epidemiology
Herpesvirus 8, Human - immunology
Histology
HIV
Hospitals
Human herpesvirus 8
Human immunodeficiency virus
Humans
Hypertension
Infections
Internal Medicine
Liver cancer
Liver cirrhosis
Lymphocytes
Male
Medical Microbiology
Medicine
Middle Aged
Pathology
Plasma
Seroepidemiologic Studies
Serology
Thrombocytopenia
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Summary:Cirrhosis patients have immunologic insufficiency and a high seroprevalence of human herpesvirus type 8 (HHV-8). Nearly all hepatocellular carcinoma (HCC) patients are cirrhotic and have immunoabnormalities. This study aimed to assess the HHV-8 seroprevalence and hemograms in HCC patients. Blood samples from 95 HCC patients, 95 age-, sex-, and Child–Pugh class-matched cirrhotics, and 95 age- and sex-matched healthy controls were analyzed for anti-HHV-8 antibodies, HHV-8 DNA, and lymphocyte, monocyte, and platelet counts. HCC patients had lower lymphocyte and platelet counts and a higher monocyte count than the healthy controls (each p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-014-2206-8