Evaluation of the Toxic Potency of Selected Cadmium Compounds on A549 and CHO-9 Cells

Cytotoxicity of cadmium sulphide, oxide and chloride was tested using A549 and CHO-9 cells. Metabolic activity of cells (MTT test) and cell membrane permeability (NRU test) were used as cytotoxicity endpoints. The results revealed unexpectedly low toxicity of cadmium sulphide as compared to chloride...

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Bibliographic Details
Published in:International journal of occupational safety and ergonomics 2014-01, Vol.20 (4), p.573-581
Main Author: Zapor, Lidia
Format: Article
Language:English
Subjects:
Animals
cadmium chloride
Cadmium Chloride - toxicity
Cadmium compounds
Cadmium Compounds - toxicity
cadmium oxide
Cadmium sulfides
cadmium sulphide
Cell Line
Cell Membrane Permeability
Chlorides
CHO Cells
Cricetulus
Cytotoxins - toxicity
Dose-Response Relationship, Drug
Ergonomics
Humans
Lysosomes
Membranes
Oxides
Oxides - toxicity
Permeability
Sulfides - toxicity
Toxicity
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Summary:Cytotoxicity of cadmium sulphide, oxide and chloride was tested using A549 and CHO-9 cells. Metabolic activity of cells (MTT test) and cell membrane permeability (NRU test) were used as cytotoxicity endpoints. The results revealed unexpectedly low toxicity of cadmium sulphide as compared to chloride and oxide. This preliminary report does not provide any explanation for this effect, but the result may nevertheless be interesting for future studies of toxicity mechanisms of cadmium compounds. First cadmium compounds caused damage or change in the permeability of cell membranes, then inhibition of metabolic activity of mitochondria. It cannot be ruled out that the cell lysosomes are at first exposed to the effect of cadmium.
ISSN:1080-3548
2376-9130
DOI:10.1080/10803548.2014.11077080