Testosterone: More Than Having the Guts to Win the Tour de France

Sex bias in susceptibility to autoimmune diseases is evident but poorly characterized. Yurkovetskiy et al. (2013) report that host testosterone mediates changes in the microbiome to confer protection to adult male NOD mice from type 1 diabetes.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2013-08, Vol.39 (2), p.208-210
Main Authors: An, Dingding, Kasper, Dennis L.
Format: Article
Language:English
Subjects:
Androgens
Androgens - metabolism
Animals
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmunity
Bacterial Infections - immunology
Bias
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - microbiology
Disease
Epigenetics
Experiments
Female
Females
Gender differences
Genomes
Hypotheses
Immune system
Lymphocytes
Male
Males
Metabolism
Rodents
Studies
Testosterone
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Description
Summary:Sex bias in susceptibility to autoimmune diseases is evident but poorly characterized. Yurkovetskiy et al. (2013) report that host testosterone mediates changes in the microbiome to confer protection to adult male NOD mice from type 1 diabetes.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2013.08.015