Silencing D. melanogaster lgr1 impairs transition from larval to pupal stage

Highlights • Silencing lgr1 impairs pupariation in Drosophila melanogaster. • Lgr1 silenced larvae display low ecdysteroid titers and low transcript levels of spok and sad. • Lgr1 silenced larvae show decreased transcript levels for sgs4 and ilp6 and weigh less than control larvae. • Transcript prof...

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Bibliographic Details
Published in:General and comparative endocrinology 2014-12, Vol.209, p.135-147
Main Authors: Vandersmissen, Hans Peter, Van Hiel, Matthias Boris, Van Loy, Tom, Vleugels, Rut, Vanden Broeck, Jozef
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Drosophila
Drosophila melanogaster
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila Proteins - genetics
Drosophila Proteins - physiology
Ecdysteroid
Endocrinology & Metabolism
Female
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Silencing
Glycoprotein hormone
GTP-Binding Protein alpha Subunits - genetics
GTP-Binding Protein beta Subunits - genetics
Larva - growth & development
Leucine-rich repeats containing GPCR (LGR)
Male
Metamorphosis
Metazoa
Phylogeny
Pupa - growth & development
Pupariation
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - physiology
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Summary:Highlights • Silencing lgr1 impairs pupariation in Drosophila melanogaster. • Lgr1 silenced larvae display low ecdysteroid titers and low transcript levels of spok and sad. • Lgr1 silenced larvae show decreased transcript levels for sgs4 and ilp6 and weigh less than control larvae. • Transcript profiles were determined for Drosophila melanogaster lgr1 , gpa2 and gpb5.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.08.006