Echinoderm regeneration: an in vitro approach using the crinoid Antedon mediterranea

Among echinoderms, crinoids are well known for their remarkable regenerative potential. Regeneration depends mainly on progenitor cells (undifferentiated or differentiated), which migrate and proliferate in the lesion site. The crucial role of the “progenitor” elements involved in the regenerative p...

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Bibliographic Details
Published in:Cell and tissue research 2014-10, Vol.358 (1), p.189-201
Main Authors: Di Benedetto, Cristiano, Parma, Lorenzo, Barbaglio, Alice, Sugni, Michela, Bonasoro, Francesco, Candia Carnevali, Maria Daniela
Format: Article
Language:English
Subjects:
Animals
Antedon mediterranea
Aquatic plants
Biomedical and Life Sciences
Biomedicine
Cell culture
Cell Dedifferentiation - physiology
Cell Differentiation - physiology
Cell Movement - physiology
Cell Proliferation - physiology
Cellular biology
Echinodermata
Echinodermata - cytology
Echinodermata - physiology
feathers
Genotype & phenotype
Human Genetics
Marine
Models, Biological
Molecular Medicine
phenotype
Proteomics
Regeneration - physiology
Regular Article
stem cells
Stem Cells - cytology
Stem Cells - physiology
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Summary:Among echinoderms, crinoids are well known for their remarkable regenerative potential. Regeneration depends mainly on progenitor cells (undifferentiated or differentiated), which migrate and proliferate in the lesion site. The crucial role of the “progenitor” elements involved in the regenerative processes, in terms of cell recruitment, sources, and fate, is a central problem in view of its topical interest and biological implications. The spectacular regenerative potential of crinoids is used to replace lost internal and external organs. In particular, the process of arm regeneration in the feather star Antedon mediterranea is the regeneration model most extensively explored to date. We have addressed the morphological and functional characterization of the cell phenotypes responsible for the arm regenerative processes by using an in vitro approach. This represents the first successful attempt to culture cells involved in crinoid regeneration. A comparison of these results with others from previous in vivo investigations confirms the diverse cell types contributing to regeneration and underscores their involvement in migration, proliferation, and dedifferentiation processes.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-014-1915-8