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Cyclic Changes in HIV Shedding From the Female Genital Tract During the Menstrual Cycle

Factors increasing genital human immunodeficiency virus (HIV) shedding may increase female-to-male HIV transmission risk. We examined HIV shedding in 67 women with HIV type 1 and herpes simplex virus type 2 coinfection, during 2 menstrual cycles. Shedding occurred in 60%, 48%, and 54% of samples dur...

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Bibliographic Details
Published in:The Journal of infectious diseases 2013-05, Vol.207 (10), p.1616-1620
Main Authors: Curlin, Marcel E., Leelawiwat, Wanna, Dunne, Eileen F., Chonwattana, Wannee, Mock, Philip A., Mueanpai, Famui, Thep-Amnuay, Sukhon, Whitehead, Sara J., McNicholl, Janet M.
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Language:English
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Summary:Factors increasing genital human immunodeficiency virus (HIV) shedding may increase female-to-male HIV transmission risk. We examined HIV shedding in 67 women with HIV type 1 and herpes simplex virus type 2 coinfection, during 2 menstrual cycles. Shedding occurred in 60%, 48%, and 54% of samples during the follicular, periovulatory, and luteal phases, respectively (P = .01). Shedding declined after menses until ovulation, with a slope -0.054 log 10 copies/swab/day (P < .001), corresponding to a change of approximately 0.74 log 10 copies between peak and nadir levels. Shedding increased during the luteal phase only among women with CD4 counts of
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jit063