Autophagy Meets Phagocytosis

Autophagy can degrade intracellular bacteria, but how this pathway contributes to phagocytosis is unclear. In this issue of Immunity, Bonilla et al. (2013) demonstrate an additional role for autophagy in Mycobacterium tuberculosis internalization by macrophages.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2013-09, Vol.39 (3), p.425-427
Main Authors: Cadwell, Ken, Philips, Jennifer A.
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Animals
Autophagy
Autophagy - immunology
Autophagy-Related Protein 7
Bacteria
Bacterial infections
Experiments
Genes
Heat-Shock Proteins - metabolism
Infections
Microtubule-Associated Proteins - metabolism
Mycobacterium tuberculosis
NF-E2-Related Factor 2 - metabolism
Phagocytosis - immunology
Receptors, Immunologic - biosynthesis
Rodents
Scavenger Receptors, Class A - biosynthesis
Sequestosome-1 Protein
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Description
Summary:Autophagy can degrade intracellular bacteria, but how this pathway contributes to phagocytosis is unclear. In this issue of Immunity, Bonilla et al. (2013) demonstrate an additional role for autophagy in Mycobacterium tuberculosis internalization by macrophages.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2013.08.027