A systematic review of therapeutical approaches in bisphosphonates-related osteonecrosis of the jaw (BRONJ)

Summary Objectives: The clinical management of bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains controversial. Since universally accepted guidelines have not been released yet, clinicians usually chose the type of treatment according to position papers based on expert opinion, or on e...

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Bibliographic Details
Published in:Oral oncology 2014-11, Vol.50 (11), p.1049-1057
Main Authors: Rupel, Katia, Ottaviani, Giulia, Gobbo, Margherita, Contardo, Luca, Tirelli, Giancarlo, Vescovi, Paolo, Di Lenarda, Roberto, Biasotto, Matteo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bisphosphonate-Associated Osteonecrosis of the Jaw - therapy
Bisphosphonates
Bones, joints and connective tissue. Antiinflammatory agents
Hematology, Oncology and Palliative Medicine
Humans
Medical sciences
Nonsurgical approaches
Osteonecrosis
Otolaryngology
Otorhinolaryngology. Stomatology
Pharmacology. Drug treatments
Surgical approaches
Systematic review
Therapeutical approaches
Tumors
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Summary:Summary Objectives: The clinical management of bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains controversial. Since universally accepted guidelines have not been released yet, clinicians usually chose the type of treatment according to position papers based on expert opinion, or on empirical experience. The aim of this systematic review is to identify different therapeutical approaches for BRONJ that have been described in literature and to describe their effectiveness. Materials and Methods: A Medline via Pubmed and Scopus database literature search was conducted and all publications fulfilling the inclusion and exclusion criteria were included in eligibility assessment. The full texts of 146 retrieved articles were then screened and 40 studies were included in the quality assessment process. Results: After quality assessment, 22 full text articles were selected for the final review. 14 articles out of 22 were screened for stage-related outcomes. The overall outcome results and results for every disease stage were the highest when patients were treated with extensive surgery or extensive laser assisted surgery.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2014.08.016