Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis

Purpose To report a rare case of pituitary metastasis (PM) from hepatocellular carcinoma (HCC) and help better understand the incidence of PM and its most common presenting symptoms through a pooled individual patient data analysis. Methods Literature regarding PM was systematically reviewed with a...

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Bibliographic Details
Published in:Pituitary 2015-02, Vol.18 (1), p.159-168
Main Authors: He, Wenzhuan, Chen, Fangxiang, Dalm, Brian, Kirby, Patricia A., Greenlee, Jeremy D. W.
Format: Article
Language:English
Subjects:
Adult
Aged
Breast Neoplasms - pathology
Diabetes Insipidus - pathology
Endocrinology
Human Physiology
Humans
Hypopituitarism - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Metastasis - pathology
Pituitary Gland - pathology
Pituitary Neoplasms - pathology
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Summary:Purpose To report a rare case of pituitary metastasis (PM) from hepatocellular carcinoma (HCC) and help better understand the incidence of PM and its most common presenting symptoms through a pooled individual patient data analysis. Methods Literature regarding PM was systematically reviewed with a pooled individual patient data analysis conducted. Pooled individual data analysis result is also compared with the result in a most recent systematic review. Results Our results demonstrate that the incidence of PM among all intracranial metastases is 0.87 % (95 % CI 0.56, 1.18); it is 1.9 % (95 % CI 1.46, 2.34) among all autopsied cancer cases; it is 11.56 % (95 % CI 7.08, 16.04) among all breast cancer patients who had hypophysectomies and 12.83 % (95 % CI 10.5, 15.16) among all autopsied breast cancer patients. The fixed effect model showed that the incidence of PM in breast cancer patients group is significantly higher ( p  
ISSN:1386-341X
1573-7403
DOI:10.1007/s11102-014-0552-2