Cytogenetic classification in Korean multiple myeloma patients: prognostic significance of hyperdiploidy with 47-50 chromosomes and the number of structural abnormalities

Chromosomal abnormalities are important prognostic factors for patients diagnosed with multiple myeloma (MM). We retrospectively reviewed the clinical and laboratory data of 525 MM patients to assess the abnormalities frequently found by conventional cytogenetic analysis and to determine their relat...

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Bibliographic Details
Published in:European journal of haematology 2014-04, Vol.92 (4), p.313-320
Main Authors: Lim, Ji-Hun, Seo, Eul-Ju, Park, Chan-Jeoung, Jang, Seongsoo, Chi, Hyun-Sook, Suh, Cheolwon, Kim, Hawk, Kim, Sung-Ryul
Format: Article
Language:English
Subjects:
1q amplification
Abnormal Karyotype
Adult
Aged
Aged, 80 and over
Chromosome Aberrations
complex chromosomal abnormality
cytogenetics
Female
Humans
hyperdiploidy
In Situ Hybridization, Fluorescence
Male
Middle Aged
multiple myeloma
Multiple Myeloma - diagnosis
Multiple Myeloma - genetics
Multiple Myeloma - mortality
Neoplasm Staging
Polyploidy
Prognosis
Republic of Korea
Risk Factors
Survival Analysis
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Summary:Chromosomal abnormalities are important prognostic factors for patients diagnosed with multiple myeloma (MM). We retrospectively reviewed the clinical and laboratory data of 525 MM patients to assess the abnormalities frequently found by conventional cytogenetic analysis and to determine their relationship to prognosis and clinical parameters. Samples from 222 (42.3%) patients had abnormal karyotypes. Hyperdiploidy‐1 (>50 chromosomes), hyperdiploidy‐2 (47–50 chromosomes), pseudodiploidy (46 with abnormalities), and hypodiploidy (
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.12257