Anaphylaxis to succinylated gelatin in a patient with a meat allergy: galactose-α(1, 3)-galactose (α-gal) as antigenic determinant

Abstract Specific immunoglobulin E (sIgE) antibodies towards the galactose-α(1,3)-galactose (α-gal) moieties may elicit life-threatening and fatal anaphylactic reactions. Patients sensitized to α-gal moieties from mammalian meat may also react towards mammalian gelatins and gelatin-containing drugs...

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Bibliographic Details
Published in:Journal of clinical anesthesia 2014-11, Vol.26 (7), p.574-576
Main Authors: Uyttebroek, A., MD, Sabato, V., MD, Bridts, C.H., MSc, De Clerck, L.S., MD, PhD, Ebo, D.G., MD, PhD
Format: Article
Language:English
Subjects:
Anaphylaxis - chemically induced
Anesthesia & Perioperative Care
Animals
Disaccharides - immunology
Epitopes - immunology
Female
Food Hypersensitivity - complications
Gelatin - adverse effects
Gelatin allergy
Humans
Immunoglobulin E - blood
Meat - adverse effects
Middle Aged
Pain Medicine
Perioperative anaphylaxis
Skin Tests
Succinates - adverse effects
α-gal allergy
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Summary:Abstract Specific immunoglobulin E (sIgE) antibodies towards the galactose-α(1,3)-galactose (α-gal) moieties may elicit life-threatening and fatal anaphylactic reactions. Patients sensitized to α-gal moieties from mammalian meat may also react towards mammalian gelatins and gelatin-containing drugs such as bovine gelatin-based colloid plasma substitute. The case of a 56 year old woman with a meat allergy who suffered anaphylaxis to succinylated gelatin is reported.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2014.04.014