Impact of obesity on the efficacy of ustekinumab in Japanese patients with psoriasis: a retrospective cohort study of 111 patients

Obesity is thought to be involved in the pathogenesis of psoriasis, although its impact on the therapeutic response to systemic treatments remains unclear. The aim of this study was to examine the association of body mass index (BMI) with the efficacy of ustekinumab in Japanese patients with psorias...

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Bibliographic Details
Published in:Archives of Dermatological Research 2014-12, Vol.306 (10), p.921-925
Main Authors: Yanaba, Koichi, Umezawa, Yoshinori, Ito, Toshihiro, Hayashi, Mitsuha, Kikuchi, Sota, Fukuchi, Osamu, Saeki, Hidehisa, Nakagawa, Hidemi
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Monoclonal, Humanized - therapeutic use
Asian Continental Ancestry Group
Body Mass Index
Dermatology
Female
Humans
Immunosuppressive Agents - therapeutic use
Japan
Male
Medicine
Medicine & Public Health
Middle Aged
Obesity - diagnosis
Obesity - ethnology
Obesity - physiopathology
Original Paper
Patient Selection
Psoriasis - diagnosis
Psoriasis - drug therapy
Psoriasis - ethnology
Psoriasis - immunology
Retrospective Studies
Time Factors
Treatment Outcome
Ustekinumab
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Summary:Obesity is thought to be involved in the pathogenesis of psoriasis, although its impact on the therapeutic response to systemic treatments remains unclear. The aim of this study was to examine the association of body mass index (BMI) with the efficacy of ustekinumab in Japanese patients with psoriasis. Clinical data from a cohort of 111 Japanese patients treated with ustekinumab 45 mg between July 2011 and March 2014 were retrospectively evaluated. The measured outcome was improvement in the psoriasis area and severity index (PASI) score at week 16. Patients with BMI ≥ 25 and BMI 
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-014-1495-1