Plasma inflammatory biomarkers for Huntington’s disease patients and mouse model

Highlights • Increased plasma IL-6, MMP-9, VEGF, and TGF-β1 in HD patients. • Decreased IL-18 plasma levels in HD patients. • Plasma IL-6 reversely correlates with independence scale and functional capacity. • Alterations of the inflammatory markers were found in R6/2 mice at different ages. • These...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-02, Vol.44, p.121-127
Main Authors: Chang, Kuo-Hsuan, Wu, Yih-Ru, Chen, Yi-Chun, Chen, Chiung-Mei
Format: Article
Language:English
Subjects:
Adult
Age Factors
Allergy and Immunology
Animals
Biomarker
Biomarkers - blood
Disease Models, Animal
Female
Humans
Huntington Disease - blood
Huntington Disease - complications
Huntington Disease - diagnosis
Huntington’s disease
Inflammation
Inflammation - blood
Inflammation - complications
Interleukin-18 - blood
Interleukin-6 - blood
Male
Matrix Metalloproteinase 9 - blood
Mice
Microglia - metabolism
Middle Aged
Motor Activity
Psychiatry
Transforming Growth Factor beta1 - blood
Vascular Endothelial Growth Factor A - blood
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Summary:Highlights • Increased plasma IL-6, MMP-9, VEGF, and TGF-β1 in HD patients. • Decreased IL-18 plasma levels in HD patients. • Plasma IL-6 reversely correlates with independence scale and functional capacity. • Alterations of the inflammatory markers were found in R6/2 mice at different ages. • These inflammatory markers may serve as the potential biomarkers for HD.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.09.011