Development of Chagas Cardiac Manifestations Among Texas Blood Donors

Chagas disease, infection with the parasite Trypanosoma cruzi , has recently been identified as an important emerging parasitic disease in the United States. To describe the cardiac abnormalities in T. cruzi –positive blood donors in southeastern Texas, a pilot study of donors who had screened posit...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2015, Vol.115 (1), p.113-117
Main Authors: Garcia, Melissa N., MPH, Murray, Kristy O., DVM, PhD, Hotez, Peter J., MD, PhD, Rossmann, Susan N., MD, PhD, Gorchakov, Rodion, MS, Ontiveros, Alejandra, MD, Woc-Colburn, Laila, MD, Bottazzi, Maria Elena, PhD, Rhodes, Charles E., BS, Ballantyne, Christie M., MD, Aguilar, David, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Blood & organ donations
Blood Donors
Cardiomyopathy
Cardiovascular
Cardiovascular disease
Chagas Disease - diagnosis
Chagas Disease - epidemiology
Chagas Disease - transmission
Coronary vessels
Diabetes
Echocardiography
Electrocardiography
Female
Follow-Up Studies
Heart
Heart attacks
Hispanic people
Humans
Hypertension
Incidence
Infections
Male
Middle Aged
Morbidity
Mortality
Pilot Projects
Population
Protozoa
Retrospective Studies
Risk Assessment - methods
Risk Factors
Studies
Survival Rate - trends
Texas - epidemiology
Trypanosoma cruzi
Ultrasonic imaging
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chagas disease, infection with the parasite Trypanosoma cruzi , has recently been identified as an important emerging parasitic disease in the United States. To describe the cardiac abnormalities in T. cruzi –positive blood donors in southeastern Texas, a pilot study of donors who had screened positive from 2007 to 2012 was performed. This one-time assessment included (1) a questionnaire to evaluate the source of infection, cardiac symptoms, and health co-morbidities; (2) electrocardiography; (3) echocardiography if electrocardiographic findings were abnormal; and (4) measurement of a high-sensitivity troponin T biomarker. Of those with confirmed infection, 41% (7 of 17) had electrocardiographic abnormalities consistent with Chagas cardiomyopathy. In addition, 36% (6 of 17) were suspected to be locally acquired cases. High-sensitivity troponin T serum levels increased with cardiac severity. In conclusion, cardiologists should consider Chagas disease in their differential diagnoses for patients who may have clinically compatible electrocardiographic changes or nonischemic cardiomyopathy, even if the patients have no histories of residing in Chagas-endemic countries.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2014.09.050