PROTECTIVE ROLE OF VITAMIN C AND GREEN TEA EXTRACT ON MALATHION-INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN RATS

This present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group...

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Bibliographic Details
Published in:American journal of pharmacology and toxicology 2014-03, Vol.9 (3), p.177-188
Main Authors: Elzoghby, Rabab R., Hamoda, Ahlam F., Abed-Ftah, A., Farouk, Mona
Format: Article
Language:English
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Summary:This present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group three and Group four were given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks) plus vitamin C (200 mg/kg/day) and plus green tea (36 mg/kg/day) respectively. At the end of the fourth week, the malathion-treated group had significantly lower Red Blood Cell count, Hemoglobin concentration, Packed Cell Volume and leucocytes than the control group. Compared to the control group, the malathion-treated group had significantly higher serum Alkaline Phosphatase, Alanine aminotransferase, Aspartate aminotransferase, Lactate Dehydrogenase, urea, creatinine and uric acid levels than the control group. Thus, vitamin C and green tea can reduce malathion hepatotoxicity and nephrptoxicity.
ISSN:1557-4962
1557-4970
DOI:10.3844/ajptsp.2014.177.188