Genetic and immunologic relationships between vaccine and field strains for vaccine selection of type A foot-and-mouth disease virus circulating in East Asia

• Published in: Vaccine 2015-01, Vol.33 (5), p.664-669
• Main Authors: Lee, Seo-Yong, Park, Min-Eun, Kim, Rae-Hyung, Ko, Mi-Kyeong, Lee, Kwang-Nyeong, Kim, Su-Mi, Shim, Hang-Sub, Kim, Byounghan, Lee, Jong-Soo, Park, Jong-Hyeon
• Format: Article
• Language: English
• Subjects: A type; Allergy and Immunology; Amino acids; Animal diseases; Animals; Antigens; Antigens, Viral - genetics; Antigens, Viral - immunology; East Asia; Far East; FMD; Foot & mouth disease; Foot-and-Mouth Disease - immunology; Foot-and-Mouth Disease - virology; Foot-and-mouth disease virus; Foot-and-Mouth Disease Virus - classification; Foot-and-Mouth Disease Virus - genetics; Foot-and-Mouth Disease Virus - immunology; Foot-and-Mouth Disease Virus - isolation & purification; Genetic diversity; Genetic Variation; Genomes; Infections; Phylogenetics; Quarantine; RNA, Viral - genetics; Sequence Alignment; Studies; Trees; Vaccine; Vaccines; Viral Structural Proteins - genetics; Viral Structural Proteins - immunology; Viral Vaccines - genetics; Viral Vaccines - immunology; Viral Vaccines - isolation & purification; Viruses
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2014.12.007

Highlights • ASIA topotype-specific sites were mainly identified in axes of VP1 and VP2. • The matching rates of topotype-specific sites were highly correlated with r -values. • Antigen differences between FMDV A types can be inferred to VP1 or VP2 similarity. • East Asian viruses during 2009–2013 had the most antigenic similarity with A Malaysia 97.