Upper aero-digestive contamination by Pseudomonas aeruginosa and implications in Cystic Fibrosis

Abstract Background Cystic Fibrosis (CF) is a severe genetic disorder that is common among the Caucasian population. Bacterial respiratory infections are the main cause of morbidity and mortality in CF patients. Pseudomonas aeruginosa is the main pathogen of lower airways (LAW) decline. Method To un...

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Bibliographic Details
Published in:Journal of cystic fibrosis 2015-01, Vol.14 (1), p.6-15
Main Authors: Rivas Caldas, R, Boisramé, S
Format: Article
Language:English
Subjects:
Cystic Fibrosis
Cystic Fibrosis - epidemiology
Cystic Fibrosis - microbiology
Cystic Fibrosis - physiopathology
Female
Humans
Incidence
Male
Mouth
Mouth - microbiology
Nasal cavity
Paranasal sinuses
Paranasal Sinuses - microbiology
Prognosis
Pseudomonas aeruginosa
Pseudomonas aeruginosa - isolation & purification
Pseudomonas Infections - diagnosis
Pseudomonas Infections - epidemiology
Pulmonary/Respiratory
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - microbiology
Risk Assessment
Survival Rate
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Summary:Abstract Background Cystic Fibrosis (CF) is a severe genetic disorder that is common among the Caucasian population. Bacterial respiratory infections are the main cause of morbidity and mortality in CF patients. Pseudomonas aeruginosa is the main pathogen of lower airways (LAW) decline. Method To understand chronic broncho-pulmonary colonization, a systematic review is conducted. The aim of our article is to identify the pathways of contamination in the upper aero-digestive tract. Results A large number of articles report that P. aeruginosa is established first at nasopharyngeal sites. The vast majority of authors agree that the upper aero-digestive tract is the first location of colonization by P. aeruginosa and its presence appears to be predictive of subsequent broncho-pulmonary colonization. Conclusion This review supports the possible involvement of the nasal and paranasal sinuses and oral cavity as means of contamination.
ISSN:1569-1993
1873-5010
DOI:10.1016/j.jcf.2014.04.008