Effects of blockade of 5-HT sub(2) receptors and activation of 5-HT sub(1A) receptors on the exploratory activity of rats in the elevated plus-maze

Acute administration of gepirone, a 5-HT sub(1A) agonist, caused a dose dependent reduction in the locomotor activity (open and closed arms) of rats tested in the elevated plus-maze. However, rats housed in individual cages and submitted to chronic treatment with gepirone showed a marked increase in...

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Bibliographic Details
Published in:Psychopharmacology 1992-01, Vol.107 (1), p.135-139
Main Authors: Motta, V, Maisonnette, S, Morato, S, Castrechini, P, Brandao, M L
Format: Article
Language:English
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Summary:Acute administration of gepirone, a 5-HT sub(1A) agonist, caused a dose dependent reduction in the locomotor activity (open and closed arms) of rats tested in the elevated plus-maze. However, rats housed in individual cages and submitted to chronic treatment with gepirone showed a marked increase in the percentages of number and time spent in the open arms as compared to controls. Ketanserin caused a biphasic effects on the exploratory behavior of rats in the plus-maze. The lower dose decreased the aversion to the open arms and the higher dose caused an unspecific decrease in the overall activity of the animals. Ketanserin is supposed to have antagonistic action on 5-HT sub(2) and on alpha -adrenergic receptors.
ISSN:0033-3158