Oncogenic nature of a novel mutant AATF and its interactome existing within human cancer cells

Since apoptosis presents a natural defense in cancer development, the anti‐apoptotic factor AATF/Che‐1 has emerged as a crucial ‘Epigenomic‐Switch’. We have tried to understand the double‐edged nature of AATF, showing for the first time the conspicuous existence of an aberrant AATF/Che‐1 transcripto...

Full description

Saved in:
Bibliographic Details
Published in:Cell biology international 2015-03, Vol.39 (3), p.326-333
Main Authors: Sharma, Shaveta, Kaul, Deepak, Arora, Mansi, Malik, Deepti
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Apoptosis
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Autophagy
Cancer
Cancer cells
Cell Line, Tumor
DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA (Cytosine-5-)-Methyltransferases - metabolism
DNA Methylation
DNA Methyltransferase 3B
DNMT3B
Down-Regulation
G1 Phase Cell Cycle Checkpoints
Gene expression
Gene regulation
HeLa Cells
Humans
Jurkat Cells
Molecular Sequence Data
Mutant-AATF
Mutants
Mutation
Neoplasms - genetics
Neoplasms - physiopathology
Oncogenomics
Promoter Regions, Genetic
Repressor Proteins - genetics
Repressor Proteins - metabolism
RNA Interference
RNA, Small Interfering - metabolism
Sp1 protein
Sp1 Transcription Factor - genetics
Sp1 Transcription Factor - metabolism
Transcriptomes
Tumor suppressor genes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since apoptosis presents a natural defense in cancer development, the anti‐apoptotic factor AATF/Che‐1 has emerged as a crucial ‘Epigenomic‐Switch’. We have tried to understand the double‐edged nature of AATF, showing for the first time the conspicuous existence of an aberrant AATF/Che‐1 transcriptome encoding for 23 kDa mutant AATF protein, which evolves its unique interactome within human cancer cells derived from different tissue origins. This mutant AATF along with its interactome consisting of SP1, DNMT3B and Par‐4 ensures cancer cell DNA methylation required for down‐regulation of tumor suppressor genes. Hence, the proposed mutant AATF interactome‐based pathway can have the inherent ability to ensure human cells become and remain cancerous.
ISSN:1065-6995
1095-8355
DOI:10.1002/cbin.10379