Inflammation and nerve fiber interaction in endometriotic pain

Highlights • The pathogenesis of endometriotic pain is not clear. • Endometriotic lesions are associated with inflammation and nerve growth. • Production of chronic pain by endometriotic lesions can permanently affect the central nervous system. • Endometriotic-associated inflammation may interact w...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2015-01, Vol.26 (1), p.1-10
Main Authors: McKinnon, Brett D, Bertschi, Dominic, Bersinger, Nick A, Mueller, Michael D
Format: Article
Language:English
Subjects:
Cell Communication
Disease Progression
Endocrinology & Metabolism
endometriosis
Endometriosis - complications
Endometriosis - pathology
Estrogens - physiology
Female
Humans
inflammation
Inflammation - complications
Inflammation - pathology
nerve
Nerve Fibers - physiology
pain
Pelvic Pain - etiology
Pelvic Pain - pathology
Pelvis - innervation
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Summary:Highlights • The pathogenesis of endometriotic pain is not clear. • Endometriotic lesions are associated with inflammation and nerve growth. • Production of chronic pain by endometriotic lesions can permanently affect the central nervous system. • Endometriotic-associated inflammation may interact with the central nervous system to produce endometriotic pain.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2014.10.003