Modulation of Cardiovascular Functions by Angiotensin II within the Brainstem of Conscious Trout, Oncorhynchus mykiss

The renin-angiotensin system appeared early during evolution, and results in teleost fish clearly demonstrated the important effector functions of circulating angiotensin II (AII) in blood pressure regulation. AII is also present in the brain of teleost fish, and autoradiographic studies have shown...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1998-05, Vol.839 (1), p.414-415
Main Authors: PAMANTUNG, TOMMY FERDINANDUS, LEROY, JEAN-PAUL, MABIN, DOMINIQUE, LE MEVEL, JEAN-CLAUDE
Format: Article
Language:English
Subjects:
Freshwater
Oncorhynchus mykiss
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Summary:The renin-angiotensin system appeared early during evolution, and results in teleost fish clearly demonstrated the important effector functions of circulating angiotensin II (AII) in blood pressure regulation. AII is also present in the brain of teleost fish, and autoradiographic studies have shown the existence of AII binding sites in the medulla oblongata of the trout. In addition, our previous studies demonstrated that intracerebroventricular injection of picomolar doses of AII in conscious trout induced a potent increase in heart rate through a receptor related to the mammalian AII - type 1 receptor (AT sub(1)). The present study focuses on the cardiovascular effects of microinjections of femtomolar doses of [Asn, Val] AII within the dorsal vagal motor nucleus of the conscious trout's brainstem.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1998.tb10817.x