Cell tracking using (19)F magnetic resonance imaging: technical aspects and challenges towards clinical applications

(19)F MRI is emerging as a new imaging technique for cell tracking. It is particularly attractive because of its potential for direct and precise cell quantification. The most important challenge towards in vivo applications is the sensitivity of the technique, i.e. the detection limit in a reasonab...

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Bibliographic Details
Published in:European radiology 2015-03, Vol.25 (3), p.726-735
Main Authors: Amiri, Houshang, Srinivas, Mangala, Veltien, Andor, van Uden, Mark J, de Vries, I Jolanda M, Heerschap, Arend
Format: Article
Language:English
Subjects:
Cell Tracking - methods
Contrast Media
Diagnostic Imaging
Fluorine-19 Magnetic Resonance Imaging - instrumentation
Fluorine-19 Magnetic Resonance Imaging - methods
Humans
Magnetic Fields
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Summary:(19)F MRI is emerging as a new imaging technique for cell tracking. It is particularly attractive because of its potential for direct and precise cell quantification. The most important challenge towards in vivo applications is the sensitivity of the technique, i.e. the detection limit in a reasonable imaging time. Optimal sensitivity can be achieved with dedicated (19)F compounds together with specifically adapted hardware and acquisition methods. In this paper we introduce the (19)F MRI technique focusing on these key sensitivity issues and review the state-of-the-art of (19)F MRI and developments towards its clinical use. We calculate (19)F detection limits reported in preclinical cell and clinical (19)F drug studies in terms of tissue concentration in a 1 cm(3) voxel, as an alternate way to compare detection limits. We estimate that a tissue concentration of a few millimoles per litre (mM) of (19)F is required for a human study at a resolution of 1 cm(3).
ISSN:1432-1084
DOI:10.1007/s00330-014-3474-5