Association between serum IgG4 concentrations and the morphology of the aorta in patients who undergo cardiac computed tomography

Abstract Background Immunoglobulin G4 (IgG4)-related disease has been suggested to be involved in cardiovascular disorders such as chronic periaortitis. However, it remains unclear whether IgG4-related immuno-inflammation affects the subclinical stages of aortic remodeling. Here, we analyzed the rel...

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Bibliographic Details
Published in:Journal of cardiology 2015-02, Vol.65 (2), p.150-156
Main Authors: Sakamoto, Aiko, MD, PhD, Ishizaka, Nobukazu, MD, PhD, FJCC, Imai, Yasushi, MD, PhD, Uehara, Masae, MD, PhD, Ando, Jiro, MD, Nagai, Ryozo, MD, PhD, FJCC, Komuro, Issei, MD, PhD, FJCC
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aorta - pathology
Aortic remodeling
Aortography
Biomarkers
Cardiac computed tomography
Cardiovascular
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Female
Humans
IgG4
Immuno-inflammation
Immunoglobulin G - blood
Inflammation - blood
Male
Middle Aged
Organ Size
Retroperitoneal Fibrosis - blood
Retroperitoneal Fibrosis - diagnostic imaging
Tomography, X-Ray Computed
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Summary:Abstract Background Immunoglobulin G4 (IgG4)-related disease has been suggested to be involved in cardiovascular disorders such as chronic periaortitis. However, it remains unclear whether IgG4-related immuno-inflammation affects the subclinical stages of aortic remodeling. Here, we analyzed the relationship between serum IgG4 concentrations and the morphology of the ascending aorta. Methods Serum concentrations of IgG4 were measured in 322 patients who underwent 320-slice cardiac computed tomography (CT). We assessed the aortic wall area and intravascular area at the portion between the aortic valve and the bifurcation of the pulmonary artery. Results In total, 174 patients (54.0%) were diagnosed to have coronary artery disease (CAD) by cardiac CT. The intravascular area was significantly larger in patients with CAD than in those without (893 mm2 vs. 811 mm2 , p = 0.001). The aortic wall area was slightly, but not significantly, larger in patients with CAD than in those without (183 mm2 vs. 176 mm2 , p = 0.051). Serum concentrations of IgG4 were significantly higher in patients with an aortic wall area of median or greater size (≥181 mm2 ) than in those with a smaller area (
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2014.04.015